Dietary Supplement Gluten Free T Exclusive Circulation Heart/Vessels Men's Health Significant research supports the cardiovascular benefits of L-arginine in promoting vascular health and blood flow. L-arginine enhances nitric oxide production in the arteries, which in turn relaxes blood vessels and maintains healthy blood flow. Perfusia Plus combines sustained-release L-arginine with nutritional cofactors that enhance nitric oxide synthesis in the blood vessels (5-MTHF and ascorbic acid), in addition to antioxidants and botanicals that promote normal blood flow (R-lipoic acid, green tea extract, and resveratrol). Perfusia-SR is available for individuals who only want to supplement with L-arginine. L-arginine is a semi-essential amino acid that is involved in multiple areas of human physiology and metabolism. It has a significant effect on endocrine function and helps regulate the release of neurotransmitter chemicals, insulin, glucagon (which has the opposite effect of insulin; i.e., it raises blood sugar), and growth hormone. However, one of L-arginine's most compelling contributions to human physiology is its role as a biological precursor of nitric oxide. The lining of the arteries (the vascular endothelium) creates nitric oxide from L-arginine, resulting primarily in the relaxation of the blood vessels. This process is important to maintaining good vascular health, heart health, reproductive health, and protection against oxidative damage. Maintaining the healthy vascular endothelium function depends on an adequate supply of L-arginine being available to these cells. Without adequate L-arginine – and the subsequent production of nitric oxide – available to the vascular endothelium, arteries don't optimally dilate, which results in less than optimal blood flow to the organs and extremities.